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Reply to Compton et al.: Paradoxical misunderstanding

Year: 2025

Type: letter

Abstract: Compton et al. ( 1 ) (CEA) claim that Peto's Paradox (PP) suggests cancer risk should correlate with body size (BS) and that our findings ( 2 ) do not refute this owing to a "modest positive correlation."However, the established understanding of PP, supported by substantial literature (including CEA's work), predicts that any such relationship would refute PP ( 3 -9 ).We report a significant association, not just a correlation, which is important given our use of a nonlinear Poisson regression model.The R 2 values for this association range from 0.445 to 0.616.We are unclear how CEA concluded that our association is "modest."CEA make several other incorrect assumptions about our study, leading to their unsupported conclusions:

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.2507210122

Authors: George Butler, Joanna Baker, Sarah R. Amend, Kenneth J. Pienta, Chris Venditti

Institutions: Johns Hopkins University, Johns Hopkins Medicine, University College London, University of Reading

Language: English

Topic: Cancer Risks and Factors

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4410085637

Cites: 10

Cited by:

Related to: 10