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Single-cell elderly blood–CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus

Year: 2025
Type: article
Study design: Observational Study
Abstract: We have generated a single-cell RNA sequencing atlas of peripheral blood and ventricular CSF in idiopathic normal pressure hydrocephalus (iNPH) patients totaling 140,207 single-cell transcriptomes. We found proinflammatory alterations in peripheral blood and CSF monocytes in iNPH patients with lower baseline cognitive function. We also identified CSF cell populations likely representing periventricular sloughing of degenerating neuroglial cells. Our findings suggest possible immune dysregulation in the blood and CSF of iNPH patients.
DOI: 10.1073/pnas.2412159122
Authors: Phan Q. Duy, Emre Kiziltug, Ana B.W. Greenberg, Neel H. Mehta, Le T. Hao, Carla Fortes, Susan Mullany, Baojian Fan, Ani Manichaikul, Andrew F. Teich, Diane Chan, Seth L. Alper, Bradley T. Hyman, Steven E. Arnold, Guy M. McKhann, Matthew P. Frosch, Kristopher T. Kahle
Institutions: Massachusetts General Hospital, University of Virginia, Columbia University, Broad Institute, Beth Israel Deaconess Medical Center, Harvard University, Massachusetts Institute of Technology
Language: English
Open Access status: hybrid
OpenAlex ID: W4410085668
FWCI: 0.356
Cites: 9
Cited by: 1
Related to: 10