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Muscle-specific isoforms of FXR1 are necessary for miR-1-mediated repression of connexin 43 and are downregulated in pediatric dilated cardiomyopathy

Year: 2025
Type: article
Abstract: The contribution of microRNAs to cardiovascular diseases has been extensively studied. However, the ability of microRNAs to regulate gene expression requires interactions with RNA-binding proteins (RBPs). Little is known about the contribution of RBPs to microRNA regulation in muscle. We now show that the muscle-specific isoforms of the RBP FXR1 are decreased in pediatric dilated cardiomyopathy hearts and are necessary for miR-1 repression of connexin 43 3' untranslated region (3' UTR), highlighting the importance of RBPs in miRNA function.
DOI: 10.1152/ajpheart.00885.2024
Authors: Danielle A. Jeffrey, Karen Dockstader, Amanda Revoredo Vicentino, Dobromir B. Slavov, Shelley D. Miyamoto, Brian L. Stauffer, Carmen C. Sucharov
Language: English
Subfield: Cancer Research
Open Access status: hybrid
Awards: G1625418467, G2100418616, G3200791956, G567307144, G6999467848, G8965355389
OpenAlex ID: W4410089545
FWCI: 0.673
Cites: 45
Cited by: 2
Related to: 10