Work

Low-frequency ultrasound reverses insulin resistance and diabetes-induced changes in the muscle transcriptome in aged mice

Year: 2025

Type: article

Abstract: This study introduces low-frequency ultrasound (LFU) as a novel, noninvasive therapy that attenuates insulin resistance- and diabetes-induced transcriptional changes in aged skeletal muscle. LFU primarily reduced inflammatory and immune-related gene expression, potentially by promoting a shift toward an anti-inflammatory (M2) macrophage profile. These findings suggest that LFU may target underlying inflammatory mechanisms of insulin resistance and diabetes in aging muscle.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00470.2024

Authors: Erik D. Marchant, Ekta Singh, Sanjay Kureel, Brandon Blair, Hanna Kalenta, Zachary D. Von Ruff, Korri S. Weldon, Zhao Lai, Michael P. Sheetz, Blake B. Rasmussen

Institutions: The University of Texas at San Antonio Health Science Center, The University of Texas Medical Branch at Galveston

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Cancer Prevention and Research Institute of Texas, National Institutes of Health, National Institute on Aging, National Cancer Institute

Awards: Mays Cancer Center at UT Health SA, Recruitment of Established Investigators, Illumina NovaSeq 6000 Sequencing System, G1821512284, G3678551249, G601438926, G7069630344, UTHSCSA Cancer Genome Sequencing and Computation Core, UTMB Claude D. Pepper Older Americans Independence Center

OpenAlex ID: W4410092740

FWCI: 0.504

Cites: 23

Cited by: 2

Related to: 10