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Peripartum Cardiomyopathy and Thrombosis – A Match Made In Hell!

Year: 2025

Type: article

Abstract: Pregnancy with peripartum cardiomyopathy (PPCM) is associated with a prothrombotic state. The procoagulant system is activated, signaled by the elevated levels of clotting factors. The natural anticoagulation mechanisms are suppressed, along with the fibrinolytic system. Heart failure (HF) is also known to activate platelets favoring thrombus formation. HF with reduced ejection fraction secondary to multi-factorial etiology in PPCM predisposes to intracardiac thrombus formation and embolic complication, jeopardizing maternal and fetal safety. Anticoagulation with heparin for thrombo-prophylaxis and treatment can prevent the formation and extension of the clot. Risk stratification, prompt identification of patients with intracardiac thrombus, and timely initiation of anticoagulation can mitigate the catastrophic thromboembolic episodes.

Source: Journal of Cardiac Critical Care TSS

DOI: 10.25259/jccc_47_2024

Authors: Mohanish Badge, L. S. Nagashweta, Krithika Rajgopalan, Klaus Görlinger, Poonam Malhotra Kapoor

Institutions: All India Institute of Medical Sciences, Essen University Hospital

Language: English

Topic: Cardiovascular Issues in Pregnancy

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4410101008

FWCI: 0.649

Cites: 25

Cited by: 1

Related to: 10