Work

Sustained Effectiveness of Doxycycline Post-Exposure-Prophylaxis in a Large Sexual Health Clinic Over 96 Weeks: An Interrupted Time Series Analysis

Year: 2025

Type: article

Study design: Observational Study

Abstract: Doxycycline post-exposure prophylaxis (doxy-PEP) reduced bacterial sexually transmitted infection (STI) incidence in a sexual health clinic over 96 weeks (N = 4592; 2524 on doxy-PEP), particularly for chlamydia and syphilis, with smaller effects for gonorrhea. Continued surveillance for gonorrhea and antibiotic resistance is essential to evaluate doxy-PEP's long-term effectiveness.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciaf234

Authors: Matthew A Spinelli, Megan J Heise, Jorge Roman, Jason Bena, Michael P Barry, Susan P Buchbinder, Hyman M Scott

Institutions: University of California, San Francisco, San Francisco AIDS Foundation, San Francisco Department of Public Health

Language: English

Topic: HIV/AIDS Research and Interventions

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Norges Idrettshøgskole, National Institutes of Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases

Awards: G2007439784, Evaluation of doxycycline post-exposure prophylaxis to reduce sexually transmitted infections in PrEP users and HIV-infected men who have sex with men, Developing a U.S. National Cohort to Improve Virologic Suppression among Stimulant-using Men Living with HIV., Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEP

OpenAlex ID: W4410106395

FWCI: 3.522

Cites: 11

Cited by: 5

Related to: 10