Year: 2025
Type: article
Abstract: The article presents materials on the study of stability and establishment of terms and conditions of storage of hypochlorous acid solution obtained by electrochemical synthesis. There is a certain connection between the concept of "shelf life", which has a temporal meaning, and the concept of "stability", which determines the quality of the medicinal product, i.e. its stability during storage. To ensure the stability of hypochlorous acid solution, strict adherence to a number of storage conditions is required: the absence of UV and visible light spectrum, foreign impurities, maintaining the required acidity and temperature range. As a result of the conducted studies on the study of the stability of hypochlorous acid solution, it was established: under conditions of accelerated aging, under the influence of visible light, at a temperature of (25±2 ºС) in a transparent, colorless, plastic container, which was periodically opened, a decrease in concentration by 10 % was recorded during the first month of storage. Under storage conditions at the temperature of a household refrigerator (+5±2 ºС), in a plastic container that is impervious to visible light, which was periodically opened, a decrease in concentration by 10 % was recorded after 6 months. When stored under the most comfortable conditions: a closed cabinet, hermetically sealed, opaque to visible and UV light, chemically inert container, at a temperature of 16-20±2 ºС, a decrease in concentration by 10 % was recorded after 34 months. In the study of harmlessness, during the storage of a hypochlorous acid solution (Samples 1, 2 and 3), the absence of atypical physiological reactions and death of animals was established in laboratory mice. The experimental animals were active, outwardly neat, had a satisfactory appetite, adequately reacted to sound and light stimuli, and reflex and neuromuscular excitability were preserved. Violations of respiratory rate, heart rate, urination and defecation were not noted. Spontaneous "atypical" behavioral reactions were absent. In terms of physiological indicators, behavior, attitude to food and water, the state of the external mucous membranes, as well as the function of the gastrointestinal tract, urinary system, the experimental white mice did not differ from the animals of the control group. The shelf life of a hypochlorous acid solution obtained by electrolysis without changing biological activity (permissible drop in the concentration of the active substance by 10%) will be determined by the storage conditions, namely: when using a hermetically sealed, light-tight, chemically inert container, it is 34 months, for light-tight containers that are periodically opened - no more than 6 months, and for light-tight containers that are opened - several days.
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4410111369