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Drug-Induced Hypersensitivity Syndrome resulting in Hepatotoxicity and Epstein-Barr Virus reactivation following initiation of Levetiracetam

Year: 2025

Type: article

Abstract: A 28-year-old male with a past medical history of alcohol abuse had new-onset seizures suspected to be caused by alcohol use. Twelve days after starting levetiracetam for seizure prophylaxis, he began to develop a pruritic rash, darkening of his urine, periods of jaundice, and hot flashes that correlated with the timing of his levetiracetam dosing. He was subsequently found to have lymphocyte-predominant leukocytosis, elevated aminotransferases, and alkaline phosphatase. Following discontinuation of his levetiracetam, he was found to have positive Epstein-Barr virus (EBV) serology suggestive of reactivation. This case demonstrates levetiracetam as a rare cause of drug-induced hypersensitivity syndrome (DIHS) along with reactivation of EBV.

Source: Advances in Clinical Medical Research and Healthcare Delivery

DOI: 10.53785/2769-2779.1291

Authors: Zechariah Jung, Xavier Zonna, Samuel J Wlasowicz, Conor Banta, Lawrence Canale, Joseph Bielecki

Institutions: Lake Erie College of Osteopathic Medicine, University at Buffalo, State University of New York, Unity Health System, Geisinger College of Health Sciences

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4410113950

FWCI:

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