Work

Therapeutic mRNA vaccine applications in oncology

Year: 2025

Type: article

Abstract: The emergence of mRNA vaccines for infectious diseases has heralded development for a slew of other indications, including cancer. Lipid particle delivery vehicles can protect RNA from degradation and promote delivery to intended targets in vivo. In this mini-review, we discuss mRNA vaccine mechanisms and capacity for enhancement followed by progress to date in the clinical development of mRNA cancer vaccines and implications of mRNA localization patterns and biologic response correlates. These advances position emerging mRNA biotechnologies for success against personalized diseases such as cancer.

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2025.04.044

Authors: Leighton Elliott, Timothy Foster, Paul Castillo, Hector Mendez-Gomez, Elias J. Sayour

Institutions: University of Florida Health, University of Florida

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500