Work

Biocatalysis-driven CO2 valorization: Innovations and sustainable strategies in conversion and utilization

Year: 2025

Type: article

Abstract: Anthropogenic CO 2 emissions, a primary driver of global warming, necessitate innovative technologies to reconcile carbon neutrality with industrial growth. Biocatalysis, leveraging the precision of enzymatic systems, has emerged as a pivotal strategy for CO 2 valorization within CO 2 conversion and utilization (CCU) frameworks, enabling sustainable conversion of CO 2 into platform chemicals and fuels. This review examines cutting-edge advances in biocatalytic CO 2 conversion, with a focus on enzyme engineering breakthroughs that enhance catalytic efficiency and product selectivity. Key enzymes—including (de)carboxylases, carbon monoxide dehydrogenase, and formate dehydrogenases—are analyzed for their roles in CO 2 fixation, alongside immobilization techniques that improve operational stability. Furthermore, sophisticated protein engineering approaches, including directed evolution and rational design, are emphasized for their potential to improve enzymatic performance through tailored modifications. By bridging molecular-scale innovations with system-level engineering, this work underscores biocatalysis as a multi-faceted solution for sustainable CO 2 utilization. This contribution provides a comprehensive overview of current achievements and future perspectives in the field, emphasizing the role of biocatalysis in addressing global climate challenges.

Source: Carbon Capture Science & Technology

DOI: 10.1016/j.ccst.2025.100437

Authors: Lin Yuan, Emmanuel Mintah Bonku, Zhong-Hua Yang