Multi-therapeutic strategy targeting Akt-mTOR and FoxO1 pathway to counteract skeletal muscle atrophy consecutive to hypoxia
Year: 2025
Type: article
Abstract: Our research demonstrates that combining electrical stimulation, BCAA supplementation, and oxygenation effectively counteracts hypoxia-induced muscle atrophy. Unlike isolated treatments, this multi-therapy approach significantly improves myotube morphology and regulates key protein homeostasis pathways, with mTOR activation protein and reduced myostatin expression. These findings highlight the enhanced therapeutic potential of combining physical activity, nutritional support, and oxygen therapy to prevent muscle atrophy in the detrimental reduction of oxygen supply.
Authors: Samir Bensaid, Claudine Fabre, Amir Yahya Rajaei, Charlotte Claeyssen, Frédéric N. Daussin, Caroline Cieniewski-Bernard
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4410119780