Renal antigen-presenting cells from ANG II hypertensive donors transfer blood pressure and promote sodium retention
Year: 2025
Type: article
Abstract: Ablation of APCs prevented Ang II-induced hypertension, NKCC2 activation, and preserved natriuresis. Transfer of renal APCs from Ang II-mice increased BP and reduced natriuresis in recipient mice; renal APCs from normotensive mice or splenic APCs from Ang II-infused mice had no effect. The effect of renal APCs was dependent on the presence of T cells. Renal APCs from Ang II-mice showed preferential destination to the kidney and increased expression of cytokines.
Authors: Patricio Araos, Pablo León, Ignacio Gallegos-Pérez, Carolina Schäfer, Richard García-Betancourt, Edison Salas-Huenuleo, Carolina Prado, Víctor Barrientos, Jessica Liberona, Tomohiro Kojimahara, Stefanny M. Figueroa, Cristián A. Amador, Leandro J. Carreño, Marcelo J. Kogan, Alexis A. Gonzalez, Rodrigo Pacheco, Rodrigo Alzamora, Heddwen L. Brooks, Luis Michea
Institutions: Universidad Autónoma de Chile, University of Chile, San Sebastián University, Fundación Ciencia and Vida, Universidad de Los Andes, Universidad de Los Andes, Chile, Universidad de Los Andes, Pontificia Universidad Católica de Valparaíso, Advanced Center for Chronic Diseases, Tulane University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: ACTIVATION OF RENAL DENDRITIC CELLS BY DIETARY CHLORIDE IS A NECESSARY STEP FOR THE DEVELOPMENT OF ARTERIAL HYPERTENSION, ROLE IN SODIUM HOMEOSTASIS AND HYPERTENSION OF A NOVEL MOLECULAR MECHANISM THAT MEDIATES THE ACTION OF ALDOSTERONE IN TARGET TISSUES REGULATION OF THE BETA-3 SUBUNIT OF THE SODIUM PUMP., G2254562188, G2480279279, MODULATION OF T CELL RESPONSES BY ACTIVATION OF TYPE I AND TYPE II NATURAL KILLER T CELLS USING A PARTIALLY HUMANIZED MOUSE MODEL, REGULATION OF RENAL TUBULAR SODIUM REABSORPTION BY AMP-ACTIVATED PROTEIN KINASE ON ANGIOTENSIN II-INDUCED HYPERTENSION., G4193574107, EVALUATING THE ROLE OF THE SHORT-CHAIN FATTY ACIDS RECEPTOR GPR43 IN THE REGULATION OF CENTRAL NERVOUS SYSTEM AUTOIMMUNITY BY GUT MICROBIOTA, G4713779614, G5242104618, EVALUATING THE PRO-INFLAMMATORY ROLE OF NGAL RECEPTOR IN THE PROGRESSION OF PROTEINURIC CHRONIC KIDNEY DISEASE, G5962957151, CENTRO AVANZADO DE ENFERMEDADES CRONICAS/ ADVANCED CENTER FOR CHRONIC DISEASES (ACCDIS), DECIPHERING THE ROLE OF THE HETEROMERIC COMPLEX FORMED BY DOPAMINE RECEPTORS D2 AND D3 IN THE CONTROL OF REGULATORY T CELL FUNCTION IN THE GUT MUCOSA, ROLE OF NEUTROPHILS IN EXPERIMENTAL ARTERIAL HYPERTENSION A NEW IMMUNE PLAYER?, G7106515422, G7371971245, T Cell-Mediated Regulation of Blood pressure In Postmenopausal Hypertension, CENTRO DE ESTUDIOS AVANZADOS DE ENFERMEDADES CRONICAS (ACCDIS), G8794338893, G99091514
OpenAlex ID: W4410120003