PANoptosis: A Coordinated Response in the Diversity of Cell Death
Year: 2025
Type: article
Abstract: The recently introduced concept of PANoptosis describes a highly regulated mechanism involving the coordinated action of pyroptosis, apoptosis, and necroptosis. However, none of these three types of cell death can explain this concept alone. PANoptosis is mediated by a structure called the PANoptosome. PANoptosome components can be formed in different ways according to triggers and receptor interactions. Therefore, stimulators and regulators become central to understanding the mechanism of PANoptosis. In this review, the mechanism of PANoptosis was summarized in general, and PANoptosome regulators in the literature were discussed collectively. We aimed to contribute to the possible therapeutic approaches.
Source: Turkish Journal of Immunology
Authors: Mert Karaca, Haluk Barbaros Oral
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410124901