Effects of Intrathecal Morphine Administration in Patients Undergoing Total Abdominal Hysterectomy
Year: 2025
Type: article
Abstract: Introduction. Hysterectomy is one of the most common gynecological operations, second only to cesarean section, which is performed to treat many diseases of the female reproductive system. Therefore, it is extremely important to help women undergo this operation with the most «gentle» course of the peri- and postoperative period. Objective. The aim was to determine and investigate the effects of intrathecal morphine administration and to conclude whether intrathecal morphine improves the quality of the peri- and postoperative period. Materials and methods. The results of surgical treatment of 38 women who underwent total abdominal hysterectomy with the use of intrathecal morphine in the Dnipro Regional Clinical Hospital named after I.I. Mechnykov of the Dnipropetrovsk Regional Council. The authors declare absent of interests conflict. Results and discussion. The inclusion of intrathecal morphine at a dose of 100 μg as a component of combined anesthesia with inhalation in total abdominal hysterectomy allows to reduce the dose of sevoflurane during anesthesia compared to the use of purely endotracheal anesthesia, and significantly improves the quality of the postoperative period. The installation of an epidural catheter, as an addition, allows to significantly prolong the time to the first use of analgetics in the postoperative period, eliminates the use of intramuscular morphine and minimizes VAS scores, but is more expensive. Conclusion: Thus, intrathecal administration of morphine contributes to a subjectively more comfortable postoperative period for patients, accelerated rehabilitation of patients, and increased satisfaction with the hospital stay.
Authors: V.V. OSADCHA, Y.Y. KOBELYATSKY
Institution: Dnipro State Medical University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410126163