Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts
Year: 2025
Type: article
Abstract: AIM: To investigate whether treatment with inhaled nitric oxide is associated with cognitive performance at age 5-6 years in preterm-born children. METHODS: We analysed preterm children from two large European cohort studies, the German Neonatal Network (GNN) (N = 3606) and the French EPIPAGE-2 cohort (N = 2579) admitted to neonatal care and followed up at age 5-6 years. Both cohorts had recorded data on iNO treatment. General cognitive ability was tested with IQ tests. Classification and Regression trees analysis was used to identify prenatal, perinatal and neonatal, clinical and social-environmental predictors of IQ. RESULTS: In both cohorts, treatment with inhaled nitric oxide was not associated with IQ at age 5-6 years. Analysis identified maternal educational level, gestational age at discharge from hospital, intraventricular haemorrhage and maternal country of birth as important factors associated with IQ scores. CONCLUSION: Treatment with inhaled nitric oxide was neither negatively nor positively associated with IQ at age 5-6 years. Neonatal and brain health, as well as socioeconomic factors are important for cognitive performance in early childhood.
Source: Acta Paediatrica
DOI: 10.1111/apa.70118
Institutions: University of Leicester, University of Warwick, Universitätsklinikum Würzburg, Monash University, Inserm, Université Paris Cité, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Centre de Recherche Épidémiologie et Statistique, Assistance Publique – Hôpitaux de Paris, University of Würzburg, Université de Lille, Centre Hospitalier Universitaire de Lille, Lille Neurosciences & Cognition, National and Kapodistrian University of Athens, Children's Hospital Agia Sophia, University Hospital Schleswig-Holstein
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,480
Funders: Equipex, Fondation PremUP, European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Fondation pour la Recherche Médicale, Fondation de France, Direction Générale de l’offre de Soins, Caisse nationale de solidarité pour l'autonomie, National Institutes of Health
Awards: G1190174568, G1931971045, G3010527862, Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility, G434337789, Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance, Deutsches Frühgeborenen Netzwerk (German Neonatal Network, GNN), Deutsches Frühgeborenen Netzwerk (German Neonatal Network, GNN), Anschlussvorhaben
OpenAlex ID: W4410127670