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Epidemiology, Survival, and Second Primary Malignancies in T‐Cell Large Granular Lymphocytic Leukemia

Year: 2025

Type: article

Abstract: Introduction: Large granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder, with limited literature available about the epidemiology, survival, and development of secondary primary malignancies (SPMs) in T-LGL. Methods: The Surveillance, Epidemiology, and End Results (SEER) 17 registry was used to identify all cases of T-LGL diagnosed between 2000 and 2019, and patients with primary T-LGL were analyzed. Results: Patients with primary T-LGL were found to have a higher incidence of SPMs compared to the general population, with increased risk for hematological malignancies seen within the first 10 years and solid tumors seen after 10 years of T-LGL diagnosis. Conclusion: Patients with primary T-LGL were found to have a higher incidence of SPMs. Further research is needed to better understand the reason for this increased risk. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.

Source: eJHaem

DOI: 10.1002/jha2.70036

Authors: Arya Mariam Roy, Sawyer Bawek, Richa Parikh, Muhammad Salman Faisal, Paola Ghione