Work

Autoimmune polyglandular syndrome type 3B: a key to diagnosing autoimmune gastritis and asymptomatic primary biliary cholangitis

Year: 2025

Type: article

Abstract: Background: Autoimmune polyglandular syndrome type 3 (APS-3) encompasses autoimmune thyroid disease and other autoimmune disorders. APS-3 is further categorized into four subtypes, with APS-3B involving gastrointestinal autoimmune diseases. In this case, we diagnosed autoimmune gastritis, a condition challenging to identify based on endoscopic findings alone, and asymptomatic primary biliary cholangitis (PBC) through the recognition of APS-3B. Case report: infection due to consideration of the APS-3 framework. Specific observations, including adherent mucus and remnants of oxyntic mucosa, guided tests for anti-endogenous antibodies, confirming autoimmune gastritis. Recognizing APS-3B prompted further evaluation for PBC, including measurement of anti-mitochondrial M2 antibody, which led to the diagnosis of asymptomatic PBC. Conclusion: Recognition of APS-3 offers a valuable framework for the differential diagnosis of autoimmune diseases. LEARNING POINTS: Autoimmune thyroid disease in a patient should raise suspicion for autoimmune polyglandular syndrome type 3 (APS-3) and other potential autoimmune conditions.If APS-3 is diagnosed, further classification is recommended, along with a thorough search for additional autoimmune diseases.APS-3 serves as a framework for the differential diagnosis of autoimmune diseases.

Source: European Journal of Case Reports in Internal Medicine

DOI: 10.12890/2025_005376

Authors: Sayaka Mabuchi, Hiroya Mabuchi, Takashi Watari

Institutions: Kyoto University, Shimane University Hospital, Kyoto University Hospital

Language: English

Topic: Liver Diseases and Immunity

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $323