Year: 2025
Type: article
Abstract: Single-cell sequencing and spatially-resolved sequencing are two complementary techniques that allow researchers to explore how tissues are constructed and altered during aging and disease. However, rather than performing two experiments, it is often practically, financially, and technically preferable to be able to directly map single-cell sequencing profiles directly back to their location within a tissue to understand how and why the cell has acquired its phenotype. This article details how a novel technology called Slide-tags enables single-cell sequencing whilst preserving the spatial address of profiled cells.
Source: The Biochemist
DOI: 10.1042/bio_2025_112
Author: Andrew J. C. Russell
Institutions: Broad Institute, Harvard University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410131043