Racemization of Cross-Chain Bridging Cryptands: Effects of Linker Combination on Racemization Rate
Year: 2025
Type: article
Abstract: We synthesized three 28-membered chiral cross-chain bridging cryptands ([3.3.6], [4.4.5], and [5.5.4]) with three different linker combinations. After the separation of their enantiomers, the racemization behavior of the cryptands was evaluated by chiral high-performance liquid chromatography. As the number of ethylene glycol units in the two cross-chain linkages increased, the racemization reaction proceeded slowly.
Source: Organic Letters
Authors: Taisei Maruyama, Syogo Niimi, Shinobu Miyagawa, Yuji Tokunaga
Institution: University of Fukui
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4410131117