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Electrochemical Methylthiolation of Terminal Alkynes Using Dimethyl Sulfoxide

Year: 2025

Type: article

Abstract: A protocol for terminal alkyne methylthiolation has been developed, utilizing an electrochemical strategy with dimethyl sulfoxide as both the solvent and the methylthiolating reagent. This organic electrochemical reaction, which employs commercially available reagents, proceeds efficiently at room temperature under transition‐metal‐free, external oxidant/reductant‐free, and base‐free conditions. The method affords a diverse array of alkyne sulfides in satisfactory yields and exhibits broad functional group compatibility.

Source: ChemElectroChem

DOI: 10.1002/celc.202500063

Authors: Tianci Chen, Xiaoxiao Chen, Mingming Yu, Chuan‐Ying Li

Institutions: Zhejiang Sci-Tech University, Keyi College of Zhejiang Sci-Tech University

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,750

Funders: National Natural Science Foundation of China, Zhejiang Sci-Tech University, Natural Science Foundation of Zhejiang Province