Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: To compare the features of multichannel intraluminal impedance and pH monitoring (MII-pH) tracings in children with cerebral palsy (CP) and children without CP. METHODS: Multicenter, retrospective, analytical study. We examined tracings of children aged 1 to 15 years old, evaluated from May 2017 to January 2024. Population included two groups: Group 1 consisted of children with CP, while control group comprised children without CP who had extra-digestive symptoms suggestive of gastroesophageal reflux disease (GERD) but normal MII-pH results. Quantitative data were analyzed using analysis of variance and t tests. Qualitative data were analyzed using contingency tables and chi-square tests. RESULTS: We studied 245 children. CP group included 110 children with a mean age of 5.71 years (standard deviation [SD] ± 4.24), while control group included 135 children with a mean age of 5.73 years (SD ± 3.39). The CP group had fewer reflux episodes (p = 0.0015), slower mean acid clearance time (p = 0.04), lower mean baseline impedance and mean nocturnal baseline impedance (p = 1.82e-07 and p = 7.50e-07). CONCLUSION: Children with CP have fewer reflux episodes and longer acid clearance times compared with children without CP. Prospective studies including esophagogastroduodenoscopy findings are needed to establish MII-pH reference values in children with CP.
DOI: 10.1002/jpn3.70058
Authors: Cristina Lorenzo, Cecilia Zubiri, Anabella Zosi, Sandro Miculan, Daniela Neder, Ana Rocca, Judith Cohen Sabban, Roman Bigliardi, Maria Florencia Biasoli, Manuela Manterola, Maria de los Angeles Savia, Luis Orlando Perez, Carlos Ruiz Hernández, Renata Weinschelbaum, Ana Cristina Fontenele Soares, Soraia Tahan, Veronica Plante, Christian Boggio, Soledad Arcucci, Erick Toro Monjaraz, Maria Alejandra Mortarini, Samantha Arrizabalo, Miguel Saps
Institutions: Hospital de Niños Superiora Sor María Ludovica, Garrahan Hospital, Hospital Italiano de Buenos Aires, Hospital Posadas, Hospital General de Niños Ricardo Gutierrez, Hospital El Cruce, Hospital Sant Joan de Déu Barcelona, Universidade Federal de São Paulo, Instituto Nacional de Pediatria, Hospital Universitario Austral, University of Miami
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,780
OpenAlex ID: W4410134364