Work

Microbiota-friendly diet ameliorates hypoalbuminemia in chronic kidney disease: evidence from NHANES

Year: 2025

Type: article

Abstract: Chronic kidney disease (CKD) is a global health issue, affecting approximately 10% of the population. Hypoalbuminemia, a common complication in advanced CKD, is associated with poor prognosis. This study aimed to investigate the association between a microbiota-friendly dietary scoring system (Dietary Index for Gut Microbiota, DI-GM) and serum albumin levels in patients with CKD. We utilized a cross-sectional cohort from the NHANES 2007-2018, which included 2,947 CKD patients. Multivariable logistic regression and restricted cubic spline models were applied to analyze the relationship between DI-GM scores and serum albumin. Higher DI-GM scores were significantly associated with increased serum albumin levels (β = 0.18 g/L, 95% CI: 0.07-0.28, p = 0.002). Furthermore, each 1-point increase in DI-GM score was linked to a 15% reduction in the odds of hypoalbuminemia (OR: 0.85, 95% CI: 0.74-0.97, p = 0.014). The findings suggest that a high DI-GM diet may have beneficial effects in managing hypoalbuminemia in CKD patients by modulating gut microbiota composition and reducing inflammation. This diet pattern could be a promising dietary intervention for improving clinical outcomes in CKD patients, especially those at risk for malnutrition and inflammation.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2025.1546031

Authors: Xiaoyan Wang, Pengfei Wen, Fang Gao, JinXiu Zhao, Shuchuan Miao

Institutions: First Affiliated Hospital of Chengdu Medical College, Sichuan University, West China Hospital of Sichuan University, Chengdu University of Traditional Chinese Medicine

Language: English

Topic: Dialysis and Renal Disease Management

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801