Year: 2025
Type: article
Abstract: Breast cancer ranks among the most frequently diagnosed cancers in women worldwide, driven by a multifaceted interplay of genetic, hormonal, environmental, and lifestyle influences. This paper delves into the underlying mechanisms of breast cancer progression, highlighting its molecular features and the contributions of diverse factors such as lifestyle behaviors, hormonal imbalances, and inherited genetic risks. Additionally, the biological behaviors of Luminal and HER2-enriched subtypes are discussed, along with the latest research advancements in precision medicine tailored to these subtypes. By integrating multi-omics data, this work uncovers the heterogeneity within HER2 subtypes and identifies new therapeutic targets, offering critical insights for personalized breast cancer diagnosis and treatment. The paper also reviews the most recent developments in surgery, endocrine therapy, chemotherapy, and immunotherapy, highlighting their roles in improving patient outcomes. Moreover, it explores the potential of metabolic reprogramming and targeted therapies as innovative strategies to further enhance prognosis. Looking ahead, multidisciplinary collaboration and technological advances are expected to play a pivotal role in refining the precision of breast cancer diagnosis and therapy.
Author: Mingxuan Lyu
Institution: Fujian Medical University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4410138372