Work

Web-based GTalign: bridging speed and accuracy in protein structure analysis

Year: 2025

Type: article

Abstract: Accurate protein structure alignment is essential for understanding structural and functional relationships. Here, we introduce GTalign-web, a web-based implementation of GTalign, a spatial index-driven protein structure alignment tool, designed for accessibility and high-performance structural searches. Benchmarked against the DALI and Foldseek servers, GTalign-web demonstrates superior accuracy while maintaining rapid search times. Its utility is further highlighted in annotating uncharacterized proteins through searches against UniRef30. GTalign-web provides a useful resource for protein structure analysis and functional annotation and is available at https://bioinformatics.lt/comer/gtalign. This website is free and open to all users, and there is no login requirement.

Source: Nucleic Acids Research

DOI: 10.1093/nar/gkaf398

Authors: Justas Dapkūnas, Mindaugas Margelevičius

Institution: Vilnius University

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,992

Funders: Nvidia, Lietuvos Mokslo Taryba