Work

Evaluating blue light impact on reconstructed human epidermis using laser speckle imaging

Year: 2025

Type: article

Abstract: Significance: Blue light exposure is ubiquitous in modern life, raising concerns about its potential impact on skin health. Aim: We aim to explore the effects of blue light on the reconstructed human epidermis (RHE) using the speckle analysis technique. Approach: RHE samples were irradiated with controlled doses of blue light (415 and 455 nm) at defined stages of their maturation. Following irradiation, speckle analysis was performed to assess the impact of blue light on the skin barrier. Results: Our results demonstrate that blue light irradiation significantly alters the scattering properties of RHE. Both wavelengths induced changes in the degree of linear polarization and speckle grain size, indicating disruptions in the skin barrier's structure and organization. The effects were found to be wavelength-dependent, with 455 nm irradiation showing more pronounced changes. Conclusions: Speckle imaging allowed detection of changes in the scattering properties of RHE. Findings suggest that blue light exposure can influence skin barrier function and may have implications for skin health and related conditions.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.jbo.30.5.056001

Authors: Léa Habib, Léa Abi Nassif, Marie Abboud, Rime Michael-Jubeli, Ali M. Tfayli, Roger Lteif

Institutions: Saint Joseph University, Université Paris-Saclay, Lipides: systèmes analytiques et biologiques

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,675