Work

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia

Year: 2025

Type: article

Abstract: Expression of the redox enzyme EC-SOD limits PH severity. Using vascular-selective EC-SOD depletion and SOD mimetic treatment in chronic hypoxic PH, we demonstrated that EC-SOD limits the hypoxia-induced accumulation of IMs. IMs from mice with low vascular EC-SOD were proinflammatory at baseline and enhanced ECM remodeling pathway activation in response to hypoxia. We identified Lyve1 + IMs as a perivascular, ECM-interacting subset that accumulate in hypoxia and could contribute to vascular remodeling in PH.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00399.2024

Authors: Caitlin V. Lewis, Thi-Tina N. Nguyen, Timothy E. Porfilio, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Daniel Colon Hidalgo, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Rebecca E. Oberley-Deegan, Cassidy Delaney, Eva S. Nozik

Institutions: Children's Hospital Colorado, University of Colorado Anschutz, University of Nebraska Medical Center

Language: English

Topic: Pulmonary Hypertension Research and Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Redox regulation of hyaluronan-macrophage interactions and macrophage reprogramming in pulmonary hypertension, G1230872813, G1564420345, G1855878456, G1906632938, G3138950843, G4148593637, G4652202815, G474972328, G7273972805, G7752478783, G8580154260, University of Colorado Cancer Center Support Grant, Multidisciplinary Training Program in Lung Disease

OpenAlex ID: W4410152170

FWCI: 3.543

Cites: 65

Cited by: 6

Related to: 10