Work

Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities

Year: 2025

Type: article

Abstract: The efficient photochemical synthesis of bicyclic pyrazolines using flow technology as well as the subsequent antimicrobial evaluation of these scaffolds is reported. Low minimal inhibitory concentration values of 0.5–4 μg mL−1 are found against a series of multidrug resistant bacterial strains including different Staphylococcus and Enterococcus genera species. The lead compound, which is decorated by a halogenated aryl ring system, appears to be bacteriostatic and shows excellent physicochemical and pharmacokinetic properties. Due to low levels of predicted toxicity combined with a high level of drug‐likeness, these bicyclic pyrazolines therefore are promising candidates for further studies as antibacterial species.

Source: ChemMedChem

DOI: 10.1002/cmdc.202500144

Authors: Debora Caviglia, Anna Maria Schito, Susanna Penco, Chiara Brullo, Marcus Baumann

Institutions: University of Genoa, University College Dublin

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,150