Work

A Statistical Approach toward Biofilms Hydrophilicity Characterization: Integrating ANOVA, DOE, and PCA for Starch/Glycerol/CMC Films Case Study

Year: 2025

Type: article

Abstract: A combined statistical approach significantly improves the reliability of gravimetric assessments of hydrophilicity in starch/glycerol/carboxymethylcellulose biofilms. This study reveals that traditional methods for evaluating hydrophilicity-related properties are limited by inconsistent experimental conditions and inadequate statistical design. By systematically varying film composition within a pseudocomponent domain and applying ANOVA, Mixture Design, and Principal Components Analysis, we demonstrate that composition-related effects far exceed intrinsic method variability. The results underscore the influence of components on hydrophilic behavior, offering robust and predictive models across the experimental domain. This findings-oriented approach provides a rational framework to optimize formulations, ensuring reproducible and meaningful assessments of the hydrophilicity.

Source: ACS Applied Bio Materials

DOI: 10.1021/acsabm.5c00510

Authors: Lisa Rita Magnaghi, Esther Trigueros, Raffaela Biesuz

Institutions: University of Pavia, National Interuniversity Consortium of Materials Science and Technology

Language: English

Topic: Nanocomposite Films for Food Packaging

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: Ministero dell'Università e della Ricerca