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Fluorescence-Coupled Ubiquitination Assay as a High-Throughput Screening Strategy for Novel Cereblon Degraders

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c00065

Authors: Yanan Deng, Shiling Yang, Hesong Xu, Xiyao Ding, Ying Xu, Zhengzheng Ye, Yan Chen, Zemin Zhang, Jin Lin, Huan Xiong, Zizhong Zhang, Kun Yang, Yiran Hu, Ke Xu, Cheng Luo, Shijie Chen, Hua Lin, Zhihai Li

Institutions: Chinese Academy of Sciences, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, State Key Laboratory of Drug Research, Fujian Normal University, East China Normal University, Fujian Medical University, Guiyang Medical University, China Pharmaceutical University

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Guangdong Science and Technology Department, National Key Research and Development Program of China, Natural Science Foundation of Zhejiang Province

Awards: G1042291103, G1555171643, G1746702816, G1775013976, 支架蛋白介导人巨细胞病毒衣壳组装的分子机制研究, G3114463410, G4094542154, G4240705765, G4322195117, G477706268, G4778903190, G6021871066, G7206161525, G7361198878, G793044578

OpenAlex ID: W4410153941

FWCI: 0.783

Cites: 63

Cited by: 3

Related to: 10