Work

Analysis of the multicomponent ALEX array data to examine patterns of sensitization in Cape Town, South Africa

Year: 2025

Type: article

Abstract: Introduction: This study analysed allergen sensitization patterns in Cape Town, a biodiversity-rich region with a Mediterranean climate, using ALEX® and ALEX²® multiplex component-resolved diagnostics tools. It aimed to address gaps in allergen sensitisation pattern data and complement aerobiological monitoring. Methods and results: A retrospective review of 708 adults and children attending two tertiary allergy clinics (2019-2024) found that house dust mites were the most common allergens, affecting 50%-60% of participants, with Der p 23 particularly prevalent (53%). Grass pollen sensitization was also high (46%), with 85% sensitised to the C4 grass Bermuda. Tree pollen sensitisation occurred in 29% with 14% sensitised to a diverse range of trees but neither London plane nor Cypress currently recommended in limited testing panels. Common food allergens included fruits (30%), seafood (27%), and nuts (25%), often linked to pollen cross-reactivity. Conclusion: Our study confirms a known pattern of aeroallergen sensitisation for a coastal temperate region, with increasing pollen sensitisation, particular C4 grasses. Clinicians should be aware of the diversity of tree pollen sensitisation, cross-reactivity patterns between food and pollen sensitisations and rates of minor allergen sensitisations for Blomia and animal danders when considering allergen-immunotherapies.

Source: Frontiers in Allergy

DOI: 10.3389/falgy.2025.1572509

Authors: Sarah Pedretti, Alexander Sittmann, Arné Von Hagen, Jonny Peter

Institution: University of Cape Town

Language: English

Topic: Allergic Rhinitis and Sensitization

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,077