ANKRD26-related thrombocytopenia 2 with a baseline increase in blasts: implications for clinical surveillance
Year: 2025
Type: article
Study design: Case Report
Abstract: ABSTRACT: We report on 8 patients with ankyrin repeat domain 26 (ANKRD26)-related thrombocytopenia 2 (ANKRD26-RT) with elevated bone marrow myeloblasts and dysmegakaryopoiesis, without somatic genetic abnormalities or progression to malignancy during long-term observation, findings which may constitute inherent ANKRD26-RT biology rather than progression to myeloid malignancy.
Source: Blood
Authors: Lara Wahlster, Lucy A. Godley, Jason X. Cheng, Michael W. Drazer, Christopher R. Reilly, Geraldine S. Pinkus, Jared H. Rowe, Nina Weichert-Leahey, R. Grant Rowe, Lev Gorfinkel, Karyn Brundige, Franziska Wachter, Luana Messa, Alan D. Michelson, Alan B. Cantor, Akiko Shimamura, Jacob R. Bledsoe
Institutions: Boston Children's Hospital, Harvard University, Dana-Farber Cancer Institute, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Northwestern University, Lurie Children's Hospital, Northwestern Medicine, University of Chicago, University of Chicago Medicine Comprehensive Cancer Center, Brigham and Women's Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G3745117842
OpenAlex ID: W4410159061