Work

Glucose metabolism through the hexosamine biosynthetic pathway drives hepatic de novo lipogenesis via promoting N -linked protein glycosylation

Year: 2025

Type: article

Abstract: High-glucose exposure activates both hepatic HBP and DNL pathways. The glucose metabolism into HBP is essential for the activation of the DNL pathway. ATF4 activation plays a mechanistic role in high glucose-induced HBP activation. HBP drives high glucose-induced hepatic DNL activation via promoting N-linked protein glycosylation.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00056.2025

Authors: Yanhui Li, Qing Song, Rui Guo, Yanyu Qian, Yuwei Jiang, Zhenyuan Song

Institution: University of Illinois Chicago

Language: English

Topic: Diet, Metabolism, and Disease

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute on Alcohol Abuse and Alcoholism