Work

Dyskinesia-Hyperpyrexia Syndrome in Parkinson’s Disease May Benefit from GPi Deep Brain Stimulation: A Case Report

Year: 2025

Type: article

Abstract: Background: Dyskinesia-hyperpyrexia syndrome (DHS) is a rare but life-threatening complication in Parkinson's disease (PD). Its prevention and treatment are clinical challenges. Case report: We herein present a case of a female PD patient who experienced recurrent episodes of DHS and levodopa-induced dyskinesia. The complications were alleviated after bilateral globus pallidus internus (GPi) deep brain stimulation (DBS). Discussion: Our report provides evidence that GPi DBS may reduce the susceptibility to DHS. More evidences are warranted to validate this hypothesis.

Source: Tremor and Other Hyperkinetic Movements

DOI: 10.5334/tohm.912