Work

Single-cell RNA sequencing and spatial transcriptomics reveal unique subpopulations of infiltrating macrophages and dendritic cells following AKI

Year: 2025

Type: article

Abstract: In this work, we fully characterized both single cell and spatial transcriptomes of kidney infiltrating macrophages (KIMs) and kidney dendritic cells (KDCs) following bilateral ischemia reperfusion injury. We also discovered distinct markers that differentiate KIMs from one another and kidney resident macrophages (KRMs). Finally, we show evidence suggesting that KIMs may reprogram and express genes previously limited to KRMs by day 28 following injury resolution.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00059.2025

Authors: Arin L. Melkonian, Matthew D. Cheung, Elise N. Erman, Kyle H. Moore, Jeremie M. P. Lever, Yanlin Jiang, Zhengqin Yang, Brittany N. Lasseigne, Anupam Agarwal, James F. George

Institution: University of Alabama at Birmingham

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1056151686, G1369245034, Medical Scientist Training Program, G3697042557, G4321917185, G9000010887, G9000187529, G9000334427, Response of kidney resident macrophages to proximal tubule injury, Deep South KUH Premier Research and Inter-disciplinary Mentored Education (PRIME)

OpenAlex ID: W4410160264

FWCI: 10.29

Cites: 56

Cited by: 17

Related to: 10