Correlation Between Hepatic Waveform Changes on Doppler Ultrasound and Disease Severity in Cirrhotic Patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Liver cirrhosis is the terminal stage of chronic liver disease, marked by progressive fibrosis and vascular remodeling that alters hepatic hemodynamics. Doppler ultrasonography enables non-invasive assessment of these changes by analyzing hepatic vein waveform patterns. This study aimed to evaluate the correlation between hepatic vein waveform alterations and cirrhosis severity, as classified by the Child-Pugh score, and to assess the diagnostic performance of waveform analysis in clinical staging. Methodology In this prospective, observational study, 140 patients with clinically or radiologically confirmed cirrhosis underwent Doppler ultrasonography of hepatic veins. Waveform patterns were categorized as triphasic, biphasic, or monophasic and correlated with Child-Pugh classification and other demographic and laboratory parameters. Statistical analyses assessed the strength of these associations and the diagnostic accuracy of waveform classification. Results The cohort included 59.3% males and 40.7% females, with 45% aged 41-60 years. According to Child-Pugh classification, 22.9% of patients were Class A, 25% were Class B, and 52.1% were Class C. Hepatic vein waveforms were monophasic in 38.6%, biphasic in 36.4%, and triphasic in 25% of patients. A statistically significant association was observed between waveform patterns and disease severity (p < 0.001), with 70.4% of monophasic and 68.6% of biphasic waveforms seen in Class C patients, and 57.1% of triphasic waveforms in Class A patients. Waveform changes also correlated significantly with age (p = 0.008). Diagnostic evaluation revealed 100% sensitivity and negative predictive value, along with 52.2% specificity and 69.5% positive predictive value for predicting advanced cirrhosis. Conclusions Hepatic vein waveform analysis via Doppler ultrasonography is a reliable, non-invasive indicator of cirrhosis severity, demonstrating a strong correlation with the Child-Pugh classification. Its high sensitivity and negative predictive value support its utility as a screening tool for advanced disease. Integrating waveform assessment into routine ultrasound protocols offers valuable prognostic insight without additional cost or complexity.
Source: Cureus
DOI: 10.7759/cureus.83658
Authors: Sumaiya Latheef, Shivanand Patil, Siddaroodha Sajjan, Pavan Kolekar
Institutions: Shri BM Patil Medical College, BLDE (Deemed to be University)
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410160985