Work

Altered renal vascular patterning reduces ischemic kidney injury and limits age-associated vascular loss

Year: 2025

Type: article

Abstract: Kidney vascular patterning is established through responses to guidance cues such as netrin-1; however, the significance of proper patterning to function and injury response remains unexplored. Here, utilizing a conditional knockout of netrin-1 ( Ntn1) that displays persistent abnormal arterial patterning, we identify no significant disruptions to normal kidney physiology in adult animals but, surprisingly, less tubular damage in response to ischemic injury. This study uncovers new and significant implications for proper kidney vascular patterning.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00284.2024

Authors: Sarah R. McLarnon, Samuel E. Honeycutt, Pierre-Emmanuel Y. N’Guetta, Yubin Xiong, Xinwei Li, Koki Abe, Hiroki Kitai, Tomokazu Souma, Lori L. O’Brien

Institution: Duke University

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Heart Association, North Carolina Biotechnology Center, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill

Awards: G2146124903, G3745803852, G6738261815, Uncovering Roles Of Renal Nerves During Kidney Development, G8759321297, TRIO NRSA Training Core, Trophic interactions directing proper kidney development, Pre-doctoral Training Program in Integrative Vascular Biology, Ferroptosis and Ferroptotic Stress in Maladaptive Renal Repair, Cancer Center Support Grant, G958207224

OpenAlex ID: W4410161057

FWCI: 2.412

Cites: 55

Cited by: 4

Related to: 10