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Uncovering a key enzyme opens possible therapeutic avenues for lysosomal diseases

Year: 2025

Type: article

Abstract: Lipid recycling in organelles called lysosomes depends on the lipid BMP, which was thought to be resistant to degradation by lysosomal enzymes. It emerges that the enzyme PLA2G15 breaks down BMP, and inhibiting PLA2G15 extends lifespan in a mouse model of Niemann–Pick type C1, a neurodegenerative disorder marked by impaired lysosomal lipid metabolism. Blocking the enzyme PLA2G15 prevents neuronal cell death in a mouse model of Niemann–Pick type C1 disease.

Source: Nature

DOI: 10.1038/d41586-025-01368-6

Language: English

Topic: Lysosomal Storage Disorders Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $12,690

OpenAlex ID: W4410161218

FWCI:

Cites: 4

Cited by:

Related to: 10