Cell-free nucleic acids as biomarkers of cardiovascular diseases: prospects and limitations
Year: 2025
Type: article
Abstract: One of the urgent tasks is the search for early and specific markers of cardiovascular diseases (CVD) in order to stratify the cardiovascular risk, develop methods for their prevention, early diagnosis and treatment. In recent decades, considerable attention has been paid to plasma cell-free nucleic acids free: circulating cell-free DNA (сfDNA) and circulating non-coding RNA, in particular microRNA, which are considered as promising prognostic and diagnostic biomarkers of many pathological conditions, since they play a key role in the regulation of physiological and pathophysiological processes. This review covers current understanding of the potential of plasma cfDNA and microRNA assessment in cardiovascular patients as specific biomarkers for diagnosis, risk stratification, severity assessment and monitoring of CVD, with a focus on coronary artery disease, heart failure and cardiac allograft rejection, where this area of research is promising.
Source: Russian Journal of Cardiology
Authors: L. O. Korneva, M. A. Osipova, M. A. Bortsova, D. A. Kilina, A. A. Kostareva, M. Yu. Sitnikova, A. S. Golovkin, O. V. Kalinina, P. A. Fedotov
Institution: Federal Almazov North-West Medical Research Centre
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
Funder: Russian Science Foundation
OpenAlex ID: W4410161859