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Clozapine-induced Hypertensive & Tachycardia Twirls in a Schizophrenia Patient

Year: 2025

Type: article

Abstract: The effectiveness of clozapine, a second-generation antipsychotic, in treating schizophrenia that is resistant to treatment is well established. Rare adverse effects like tachycardia and hypertension, however, might also result from it. In this case study, a 30-year-old woman with schizophrenia experienced tachycardia and chronic hypertension following clozapine medication. The patient’s heart rate and blood pressure were continuously raised, even though routine blood tests were within normal ranges. Eventually, atenolol was introduced to control these adverse effects. Although the precise mechanism by which clozapine causes tachycardia and hypertension is yet unknown, it is thought to be related to its alpha-adrenergic blocking capabilities and possible interactions with the D4 receptor. This case emphasises how crucial it is to start clozapine therapy with patients under strict observation for these unusual adverse effects

Source: Academic Bulletin of Mental Health

DOI: 10.25259/abmh_2_2025

Authors: Moumita Mandal, Chayan Kanti Manna

Institution: ICARE Institute of Medical Sciences and Research & Dr. Bidhan Chandra Roy Hospital

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4410163608

FWCI:

Cites: 14

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Related to: 10