Work

Impact of surgical bladder catheter implantation on voiding function in mice

Year: 2025

Type: article

Abstract: This study provides the first characterization of voiding behavior and bladder function changes following surgical bladder catheter implantation in mice, as measured using noninvasive assays. We show that surgical catheter implantation reduces bladder capacity and significantly alters voiding parameters, including frequency, volume, and intermicturition intervals, with overall consistent effects across sexes. These findings highlight the importance of accounting for procedural artifacts when interpreting LUT function in preclinical models, ensuring translational relevance for future studies.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00300.2024

Authors: Benjamin E. Rubin, Margaret A. Vizzard, Gerald M. Herrera

Institution: University of Vermont

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Vermont, National Institutes of Health, Larner College of Medicine, University of Vermont, National Institute of Diabetes and Digestive and Kidney Diseases