Work

Clinical implications of genetic mutations in the prognostic stratification of acral malignant melanoma

Year: 2025

Type: article

Abstract: Acral malignant melanoma (AM) is an aggressive subtype with distinct genetic and clinical features, particularly prevalent in Asian populations. This study investigated prognostic factors, surgical outcomes and molecular biomarkers to improve management strategies. A retrospective analysis of 223 AM patients (2015–2021) evaluated clinical-pathological variables (ulceration, LDH, Ki-67) through Cox regression. Surgical outcomes for heel defects were compared between traditional skin grafting (n=73) and vacuum-assisted closure (VSD; n=73). Bioinformatics analysis of TCGA data identified metastasis-associated lncRNAs, validated via qPCR in melanoma cell lines. Ulceration (HR=2.34, p

Source: International Journal of Surgery Science

DOI: 10.33545/surgery.2025.v9.i2.a.1187

Authors: Surendra Parsad Yadav, Babita Yadav

Institution: Kunming Medical University

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410165382