Impact of Smoking on SARS-CoV-2 Infection and Outcomes, An Evidence from Enrichment Analysis of Genes Associated with COVID-19 Susceptibility and Outcomes
Year: 2025
Type: article
Abstract: During the coronavirus disease-2019 (COVID-19) pandemic, genomewide association studies (GWAS) were extensively used to identify genes linked to disease outcomes, including susceptibility to infection, hospitalization, severity, and mortality.These studies have produced comprehensive lists of genes associated with different aspects of COVID-19.In this study, enrichment analysis was performed on protein-coding genes (data retrieved on July 7, 2024) using the Enrichr platform (https://maayanlab.cloud/Enrichr/).Genes were included if at least one of their polymorphisms exhibited a significant association with COVID-19 outcomes.To account for multiple comparisons and minimize false-positive results, an adjusted p-value of ≤ 0.001 was considered statistically significant.
Source: Balkan Medical Journal
Author: Mostafa Saadat
Institution: Shiraz University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410165446