Work

Comparison between the effect of ethanolic extract of L. and bisphosphonate in the treatment of induced osteoporosis in rats

Year: 2025

Type: article

Abstract: We were interested in this work to make a comparison between the protective effect of the ethanolic extract of Urtica urens L. (UU) and the effect of the bisphosphonate (BP) against osteoporosis induced in rats by intraperitoneal (IP) and oral (gavage) administration. The female rats were ovariectomized to cause osteoporosis. Several biological, histological, and histomorphometric analyses were used to study bone development. The results indicate that the EtOH extract of UU has a positive effect against osteoporosis for both routes of administration (IP and gavage). This effect could be attributed to the high richness of UU leaves in flavonoids, polyphenols, vitamins (vitamin D), and minerals (Ca and P). UU and BP have a histology score at 4 after 12 weeks of ovariectomy and for 60 days. Biological, histological, and histomorphometric studies have shown that UU and BP have significantly similar effects on the treatment of osteoporosis with both routes of administration. This plant could have a lower affinity than BP, possibly related to the dose. On the other hand, we concluded that IP administration is better than oral administration.

Source: Biomedicine & Pharmacotherapy

DOI: 10.1016/j.biopha.2025.118112

Authors: Massara Mzid, Maha Ben Jemaa, Khansa Chaabouni, Fatma Ayedi, Zouheir Sahnoun, Tarek Rebai

Institutions: University of Sfax, Faculty of Medicine of Sfax, Hopital Universitaire Habib Bourguiba

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,610