Year: 2025
Type: article
Study design: Observational Study
Abstract: Air pollution has been associated with Parkinson’s Disease (PD) risk, although this relationship remains unclear. We estimated yearly levels of exposure to ten air pollutants (period 2006–2018) in an Italian population cohort, the Moli-sani study ( N = 24,325; ≥35 years; 51.9% women), and derived three principal components, testing their associations with incident PD risk over 23,841 participants (213 cases, median(IQR) follow-up 11.2(2.0) years). This revealed a statistically significant association of PC1 (explaining 38.2% of common variance, tagging PM10 levels), independent on sociodemographic, professional and lifestyles covariates (Hazard Ratio [95%CI] = 1.04[1.02–1.07]). The association was confirmed testing average PM10 levels during follow-up (18[13–24]% increase of PD risk per 1 μg/m 3 increase of PM10). Among different circulating markers, lipoprotein a explained a significant proportion of this association (2.8[0.9; 8.4]%). These findings suggest PM10 as a target to lower PD risk at the population level and a potential implication of lipoprotein a in PD etiology.
Source: npj Parkinson s Disease
Authors: Alessandro Gialluisi, Simona Costanzo, Maria Ilenia De Bartolo, Giovanni Veronesi, Matteo Renzi, Assuntina Cembalo, Alfonsina Tirozzi, Stefania Falciglia, Moreno Ricci, Americo Bonanni, Francesco Martone, Gaetano Zazzaro, Antonietta Pepe, Daniele Belvisi, Marco Mario Ferrario, Francesco Gianfagna, Chiara Cerletti, Maria Benedetta Donati, Stefania Massari, Alfredo Berardelli, Giovanni de Gaetano, Licia Iacoviello
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,890
Funder: Ministero della Salute
Award: G756130483
OpenAlex ID: W4410172831