Work

Electrochemical Benzylic C─H Sulfation beyond the O ‐Sulfonation Limitation

Year: 2025

Type: article

Abstract: Direct C─H sulfation represents a valuable transformation for the synthesis of organosulfates. However, it has been challenging to achieve owing to the presence of multiple C─H bonds with comparable strengths and steric environments. Current methods for producing organosulfates primarily rely on O-sulfonation, which limits their applicability to hydroxyl-containing compounds. Herein, we report a practical and cost-efficient method for the electrochemical sulfation of benzylic C─H bonds. This reaction avoids the need for strong oxidants, demonstrating broad substrate scope, excellent chemoselectivity, and site selectivity. The orthogonal reactivity of this protocol is particularly evident in the transformation of alcohol substrates.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202507048

Authors: Wei Sheng, Huanhuan Peng, Ben Gao, Chunlan Song, Jiakun Li

Institutions: Hunan University, State Key Laboratory of Chemobiosensing and Chemometrics, Wuhan University

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Hunan University, Natural Science Foundation of Hunan Province

Award: 电化学诱导实现C-O成键硫酸化及其在蛋白质修饰中的应用