Work

Multifunctional nanoparticle platform for targeted delivery and vaccines

Year: 2025

Type: article

Abstract: NPs per mL of cell-free reaction; approximately 100-fold higher than current adeno-associated virus (AAV) yields and 8 times previously reported HBc VLP yields. We demonstrate platform feasibility and versatility by the surface display of a challenging-to-fold dengue fever antigen and by pharmacokinetic studies using whole-body mouse imaging. The platform supports rapid, parallel production of multiple product candidates to increase success rates for targeted therapeutics, gene therapies, imaging agents, and vaccines.

Source: iScience

DOI: 10.1016/j.isci.2025.112599

Authors: Anja S. Redecker, Medea Neek, Philip E.J. Smith, James R. Swartz

Institution: Stanford University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240