Impact of Mulberry Leaves on CCL4-Induced Acute Liver Disease in Rats
Year: 2025
Type: article
Abstract: Background and Objective: The liver is a crucial organ in the human body that contributes to metabolic processes, immune function and nutrient regulation. The objective of this study is to evaluate the effects of mulberry leaves (Morus nigra L.) on rats with acute liver injury induced by CCl4. Materials and Methods: Twenty-four male albino Sprague Dawley rats (~195±10 g) were divided into control and CCl4-induced liver injury groups. The treated group received a monthly basal diet of 2.5 and 5% mulberry leaves. Liver histopathology, body weight, organ-to-body weight ratios and feed intake were assessed. Lipid profiles and serum markers (glucose, urea, AST and ALT) were analyzed using SPSS (Mean±SD) with a significance level of p<0.05. Results: Total serum cholesterol and blood triglyceride levels were significantly lower (p<0.05) in all mulberry-fed groups, with the most notable reduction in the 5% group. The 5% mulberry leaf group also observed the best lipoprotein profile. The 5% mulberry leaf diet improved AST, ALT and serum glucose levels in rats with acute liver disease. Conclusion: Based on the results shown here, it appears that taking 5% ML daily can help improve liver functioning and shield rats from acute damage caused by CCL4.
Author: Wafaa Fauzi Abusudah
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410178390