Work

On qualitative properties of replication and transfer of conjugative plasmids encoding antibiotic resistance genes

Year: 2025

Type: article

Abstract: In order to advance in the fight against plasmid-mediated resistance, it is necessary to deepen our understanding of the role played by these DNA molecules. In this sense, the achievements obtained from experimentation validated by mathematical models have contributed to the discovery of key properties in the dynamics of antibiotic resistance. In this work, we attempt to characterize some of these properties through nonlinear functional responses of both plasmid replication and plasmid transfer. The results of the mathematical modeling performed here suggest that the emergence of antibiotic resistance in an individual due to the transfer of plasmid-borne resistance genes is directly associated with the production capacity of both recipient and donor bacteria. Whereas for persistence, in addition to bacterial replication, specific properties associated with plasmid replication and transfer are required.

Source: Computational and Applied Mathematics

DOI: 10.1007/s40314-025-03231-w

Authors: Eduardo Ibarguen-Mondragón, Lourdes Esteva, M. Victoria Otero-Espinar, Edgar Vega, Miller Cerón-Gómez

Institutions: University of Nariño, Universidad Nacional Autónoma de México, Universidade de Santiago de Compostela

Language: English

Topic: Mathematical and Theoretical Epidemiology and Ecology Models

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,390