Streamlined Identification of Metallopeptides for Intracellular Catalysis Using Positionally Addressable Combinatorial Libraries
Year: 2025
Type: article
Abstract: The discovery and development of artificial catalysts to carry out bioorthogonal reactions in living cells is a primary goal at the interface of Chemistry and Biology. Current approaches rely on time-consuming trial-and-error methods. As an alternative, we show that positionally addressable combinatorial libraries (SPOT libraries) provide a significant advantage for the efficient identification of novel catalytic metallopeptides. Using these libraries, we were able to rapidly identify catalytic β-hairpin palladopeptides capable of promoting efficient depropargylation reactions in challenging intracellular environments.
Source: ACS Catalysis
Institutions: Universidade de Santiago de Compostela, Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Universitat Autònoma de Barcelona, Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Institució Catalana de Recerca i Estudis Avançats
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: Fundación BBVA, Institute for Research in Biomedicine, Ministerio de Ciencia, Innovación y Universidades, Centres de Recerca de Catalunya, European Commission, Generalitat de Catalunya, Institució Catalana de Recerca i Estudis Avançats, Ministerio de Ciencia e Innovación, Banco Bilbao Vizcaya Argentaria, Xunta de Galicia, Agència de Gestió d'Ajuts Universitaris i de Recerca, European Regional Development Fund, Agencia Estatal de Investigación
Awards: G121809054, G1496055848, G1622782223, G1650125035, G2042483231, G2096722086, G2567692413, G2660406951, G3480869486, G3518538256, G3550760735, G3694284866, G3875822497, G3876637791, G438935270, G4442677895, G4526231891, G464105488, G4644363576, G5184901473, G5203175219, G5353516086, G5554424168, G5805502524, G5982538964, G6298273575, G6818627905, G7084143925, G7284683163, G7434936867, G762602090, G7764612811, G80286236, G877287564, G97325046
OpenAlex ID: W4410188589