Expression of MicroRNA-21 in Chronic Lymphoproliferative Disorders: A Cross-Sectional Study from India
Year: 2025
Type: article
Study design: Observational Study
Abstract: This cross-sectional study evaluated the expression of microRNA-21 (miRNA-21) in patients newly diagnosed with chronic lymphoproliferative disorders (CLPD) at a tertiary hospital in Delhi, India, between April 2023 and April 2024.A total of 26 patients were included and miRNA-21 levels were measured using quantitative PCR.Although overall miRNA-21 expression was elevated in CLPD compared to standard values, statistical significance was observed only in patients with Hodgkin and Non-Hodgkin lymphomas.No significant correlation was found between miRNA-21 expression and clinical staging systems, including Rai, Ann Arbor, and ISS.These findings suggest a potential role for miRNA-21 in lymphoproliferative diagnostics, warranting further studies with larger sample sizes for validation.
Authors: Rahul Yadav, Sunita Aggarwal, Binita Goswami, Sandeep Garg, Harpreet Singh, Pradeep Kumar, Soumia M
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410189765